The science behind PRP therapy for hair loss
PRP (platelet-rich plasma) concentrates your own growth factors to support hair follicle health. Below we outline how it works biologically, what current evidence suggests, and how we use it thoughtfully within a joined-up plan.
How PRP supports follicles (science, simplified)
Cell signalling
Platelets release growth factors that bind to follicle receptors, promoting cellular repair pathways and prolonging the hair growth (anagen) phase.
Micro-vascular boost
Factors like VEGF encourage local blood supply, helping deliver oxygen and nutrients around follicles.
Matrix support
Signals may improve extracellular matrix and dermal papilla activity, supporting thicker, more resilient shafts.
Inside a session
- We take a small blood sample and process it in a centrifuge to concentrate platelets.
- The PRP is delivered via fine injections across focus zones; numbing and gentle technique reduce discomfort.
- Aftercare is simple; we avoid strenuous scalp manipulation for 24–48 hours and review with photos.
What the research suggests
Encouraging trends
Multiple small clinical studies and reviews report improvements in hair counts and shaft calibre for pattern thinning when PRP is used over several sessions.
Benefits tend to appear gradually (over months), and are most consistent when PRP is combined with a broader plan (e.g., scalp care, nutrition checks, sensible device use).
Why results vary
- Different PRP preparation methods (single vs double spin; leukocyte content).
- Injection depth, spacing and session cadence differ between studies.
- Patient variables (age, duration of loss, hormonal/nutritional factors).
Larger, standardised trials will help refine protocols and predictability.
Limitations, safety & sensible expectations
Not a cure-all
PRP is supportive biology, not a cure. It tends to help most in early-to-moderate thinning rather than advanced loss or scarring conditions.
Side effects
Typically mild and short-lived (redness, tenderness). Rare risks are discussed at consultation; we maintain sterile technique.
Joined-up care
Scalp health, nutrition and stress management can influence outcomes. We keep plans simple, sustainable and monitored.
What to expect at Santi
1) Clinical assessment
History, photos and scalp exam (± dermoscopy) to identify pattern, triggers and realistic goals.
2) Measured plan
Where appropriate, we schedule 3 sessions 4–6 weeks apart, then review at 8–12 weeks.
3) Maintain & review
Simple home care and periodic maintenance (6–12 months) with like-for-like photography.
Further reading
Deep-dives on PRP, hormones and what to expect — written by our team.
What is PRP and how does it work?
The process, from blood draw to reinfusion.
The benefits of PRP for hair loss
Why many choose it as part of a plan.
PRP benefits & risks
A balanced look at safety and efficacy.
Is PRP right for you?
Who benefits and timelines.
What to expect during PRP
Sensation, duration and aftercare.
How to prepare for PRP
Practical steps before your session.
HRT & hair loss
Hormonal shifts and hair density.
The science behind PRP
Evidence and mechanisms.
Frequently asked questions
How many sessions are typical?
Often three sessions at 4–6-week intervals, followed by a review. Maintenance is commonly every 6–12 months, adjusted to goals and response.
Is PRP painful?
We use numbing and gentle technique. You may feel pressure or mild stinging in areas; most clients tolerate it well.
When might PRP be less suitable?
Scarring alopecias or advanced loss may respond less predictably. Auto-immune patterns (e.g., alopecia areata) usually require dermatologist-led care — we can coordinate.
What are the risks?
Typically temporary redness or tenderness at injection sites. Rare complications are discussed at consultation; we use sterile technique and medical oversight.