AGEs / Glycation Stress

Advanced Glycation End-Products (AGEs) and skin ageing

AGEs are sugar-derived compounds that can crosslink structural proteins such as collagen and elastin. We use non-invasive optical readings as **surrogate markers** of glycation burden to inform topical care, lifestyle focus and pacing of in-clinic treatments.

Matrix crosslink tendency Optical surrogate marker Plan & follow-up

What are AGEs?

Advanced Glycation End-Products form via non-enzymatic reactions between sugars and proteins, lipids or nucleic acids. In the skin, they are associated with stiffer collagen, reduced elasticity and changes in tone and texture.

How we estimate glycation burden

We use non-invasive optical methods (e.g., autofluorescence-based readings) as **surrogate indicators** of cumulative glycation in superficial tissues. Results are interpreted alongside other Skin Lab measures to avoid over-reliance on a single marker.

  • Standardised ambient lighting and device checks
  • Multiple sites averaged for consistency
  • Interpreted with hydration, TEWL, sebum, colour and elasticity context

Using your result in a practical plan

A relatively higher surrogate score may prompt emphasis on barrier support, antioxidant routines, gentle resurfacing cadence, nutrition with moderated glycaemic load, and careful spacing of in-clinic procedures. We’ll tailor this to tolerance and goals.

AGE index
Relative optical surrogate
Context panel
Hydration · TEWL · Sebum · Colour
Review
6–12 weeks (if changing routine)
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FAQs

Can skincare reduce AGEs?

Topical antioxidants and ingredients reported to **limit new crosslink formation** (e.g., carnosine) may help support the skin environment. Established crosslinks are not the same as reversible surface oxidation, so expectations should remain realistic.

Do dietary sugars matter?

Patterns with higher glycaemic load are associated with increased glycation stress. Balanced nutrition can be part of a supportive plan.

How often should I retest?

Commonly at 6–12 weeks when you’re changing routines, then less frequently once stable. Annual review is reasonable for long-term tracking.

Notes: Optical readings are surrogate indicators and do not diagnose disease. We integrate multiple measures and clinical context to guide care.

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Santi London Introduces Advanced Glycation End Product (AGE) Measurement to its Innovative Skin Lab Service

Santi London is proud to announce the addition of Advanced Glycation End Product (AGE) measurement to its comprehensive Skin Lab service. This cutting-edge offering aims to provide clients with a deeper understanding of their skin health – and to address the effects of AGE accumulation, a key contributor to skin ageing.

Skin Lab at Santi London has long been recognised as a hub of advanced skincare technology and expertise. With the introduction of AGE measurement, Santi reaffirms its place at the forefront of the industry by offering clients a comprehensive analysis of their skin’s condition.

Advanced Glycation End Products (AGEs) are known to accumulate in the skin over time, contributing to the formation of wrinkles, loss of elasticity and other signs of ageing. By measuring AGE levels, Santi Skin Lab can provide valuable insights into the impact on an individual’s skin – and tailor personalised treatment plans accordingly.

“We are thrilled to introduce AGE measurement to our Skin Lab service,” said Tariq Karim, Founder of Santi London. “Understanding the role of AGEs in skin ageing is crucial to developing effective skincare strategies. By incorporating AGE measurement into our comprehensive analysis, we can now provide our clients with even more precise and targeted recommendations.”

The Skin Lab’s AGE measurement process is non-invasive and utilises state-of-the-art technology to assess AGE levels within the skin. Highly trained skincare professionals at Santi London perform the measurements, ensuring accurate and reliable results.

In addition to AGE measurement, Santi Skin Lab offers a range of other advanced diagnostic techniques – including skin imaging, hydration analysis, sebum measurement and more. The combination of these assessments allows for a holistic evaluation of the skin’s health and assists in the development of personalised skincare regimens.

To learn more about Santi Skin Lab and the new AGE measurement service, visit www.santilondon.com/skin-lab/

Santi London is a leading skincare clinic located in the heart of South Kensington, London. With a team of highly skilled doctors, aestheticians and skincare specialists, Santi offers a wide range of advanced treatments and cutting-edge technologies to address various skin concerns. The clinic’s mission is to provide clients with exceptional skincare services, tailored treatment plans – and outstanding results.